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目的观察评价肝动脉化疗栓塞(TACE)联合灌注奥沙利铂、5-氟尿略啶及吡柔比星方案治疗原发性肝癌的可行性.疗效和安全性.方法回顾分析采用TACE术中动脉灌注奥沙利铂、5-氟尿嘧啶及吡柔比星(THP)化疗药物的原发性肝癌患者20例.对其疗效、不良反应情况进行综合评价.结果 20例中.完全缓解0例.部分缓解3例.稳定8例.进展9例;总有效率15%.临床获益率55%,19例临床症状改善;主要不良反应包括恶心、乏力、腹泻、白细胞下降、周围神经毒素.但均为轻度.患者耐受.结论肝动脉化疗栓塞联合奥沙利铂、5-氟尿嘧啶及吡柔比星灌注治疗原发性肝癌的疗效较好,不良反应少.值得进一步探讨.
Objective To evaluate the feasibility, efficacy and safety of TACE in combination with oxaliplatin, 5-fluorouridine and pirarubicin in the treatment of primary hepatocellular carcinoma.Methods Retrospective analysis of TACE Arterial infusion of oxaliplatin, 5 - fluorouracil and pirarubicin (THP) chemotherapy in patients with primary liver cancer in 20 cases.A comprehensive evaluation of the efficacy and adverse reactions.Results Of the 20 cases, complete remission in 0 cases. Partial relief in 3 cases, stable in 8 cases, progression in 9 cases, total effective rate was 15%, clinical benefit rate was 55%, and clinical symptoms of 19 cases were improved. The main adverse reactions included nausea, fatigue, diarrhea, leukopenia and peripheral neurotoxin. Were mild and patient tolerable.Conclusion The therapeutic effect of transcatheter hepatic arterial chemoembolization combined with oxaliplatin, 5-fluorouracil and pirarubicin in the treatment of primary hepatocellular carcinoma is better and less adverse reactions are worth further study.