一氧化氮是具有高度反应性的自由基 ,在体内广泛存在 ,是一种重要的细胞内信号转导分子 ,在细胞多种功能中起作用。NO主要通过提高环一磷酸鸟苷水平来实现其生物学功能。NO cGMP途径在嗜酸性粒细胞的功能中起重要作用 ,嗜酸性粒细胞在哮喘过程中能产生大量NO。两者之间存在密切联系。本文主要介绍NO cGMP信号转导通路、该通路在嗜酸性粒细胞趋化 ,凋亡等功能中作用以及NO释放在哮喘中意义的研究进展。 Nitric oxide, a highly reactive free radical, is widespread in the body and is an important intracellular signaling molecule that plays a role in multiple cellular functions. NO mainly by enhancing the level of cyclic guanosine monophosphate to achieve its biological function. The NO cGMP pathway plays an important role in the function of eosinophils, which produce large amounts of NO during asthma. There is a close relationship between the two. This article describes the NO cGMP signal transduction pathway, the pathway in eosinophil chemotaxis, apoptosis and other functions as well as NO release in the significance of asthma research.