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目的分析冠心病患者血浆白介素(IL)-6和内脂素水平与冠状动脉病变严重程度的相关性。方法选择经冠状动脉造影确诊的冠心病患者128例,分为急性冠脉综合征(ACS)组和稳定型心绞痛(SAP)组,并按病变血管支数分成3组(单支病变组、双支病变组和三支病变组),按冠状动脉狭窄程度分为3组(冠状动脉狭窄程度50%~75%组、76%~90%组及91%~100%组)。收集患者的基本临床资料,血浆IL-6及内脂素应用酶联免疫吸附法测定,应用Gensini积分评价冠状动脉病变严重程度。结果 ACS组患者IL-6及内脂素水平显著高于SAP组(P<0.05),按照不同病变血管支数分组和按照病变血管狭窄程度分组后,血浆IL-6及内脂素水平在各组间差异具有显著性(P<0.05)。相关分析显示IL-6、内脂素与Gensini积分呈正相关(分别r=0.583,r=0.724,均P<0.01)。结论 IL-6及内脂素与冠状动脉病变严重程度密切相关。
Objective To analyze the correlation between plasma interleukin-6 (IL-6) and visfatin levels and the severity of coronary artery disease (CHD) in patients with coronary heart disease. Methods One hundred and eighty-eight patients with coronary heart disease confirmed by coronary angiography were divided into acute coronary syndrome (ACS) group and stable angina pectoris (SAP) group. The patients were divided into 3 groups Branch disease group and three lesions group) were divided into 3 groups (degree of coronary stenosis 50% ~ 75%, 76% ~ 90% group and 91% ~ 100% group) according to the degree of coronary artery stenosis. The basic clinical data of patients were collected. Plasma IL-6 and visfatin were measured by enzyme-linked immunosorbent assay. Gensini score was used to evaluate the severity of coronary artery disease. Results The levels of IL-6 and visfatin in ACS group were significantly higher than those in SAP group (P <0.05). The levels of IL-6 and visfatin in plasma of patients with ACS were significantly higher than those of SAP group Differences between groups were significant (P <0.05). Correlation analysis showed that IL-6, visfatin and Gensini scores were positively correlated (r = 0.583, r = 0.724, all P <0.01). Conclusion IL-6 and visfatin are closely related to the severity of coronary artery disease.