目的:探讨滋阴补阳序贯法联合西药促排卵对PCOS患者的临床疗效。方法:回顾性分析72例多囊卵巢综合征(PCOS)患者122个促排卵周期患者的临床资料,所有患者均于促排卵前后使用滋阴补阳中药进行序贯治疗。根据促排卵方案不同分为4组,A组:克罗米芬(CC)+促性腺激素(Gn)(n=71),B组:来曲唑(LE)+Gn(n=30),C组:CC(n=14),D组:Gn(n=7),比较各组间临床和实验室指标。结果:4组妊娠率比较:C组>A组>B组>D组;Gn用量比较:D组>B组>A组,hCG注射日子宫内膜厚度:A组>D组>B组>C组,但各指标组间比较均无统计学差异(P>0.05),促排天数A组显著高于其它3组(P<0.05)。hCG注射日子宫内膜厚度<7 mm的比例CC组显著高于其它3组(P<0.05)。4组未破裂卵泡黄素化综合征(LUFS)发生率、未启动率均无统计学差异(P>0.05),无OHSS发生。按妊娠结局分组比较:bE2及bLH水平妊娠组>未孕组,差异有统计学意义(P<0.05)。妊娠组子宫内膜厚度显著高于未孕组,各组中A型内膜比例显著高于其它类型内膜。结论:对PCOS患者选择滋阴补阳序贯法联合CC+Gn促排卵能减少Gn用量,降低卵巢过度刺激综合征(OHSS)发生率,增加子宫内膜厚度,改善子宫内膜容受性,提高妊娠率。 Objective: To investigate the clinical effects of sequential nourishing yin-yang sequential therapy and ovulation induction by western medicine on patients with PCOS. Methods: A retrospective analysis of 72 cases of PCOS in patients with ovulation cycles of 122 patients with clinical data, all patients before and after ovulation with Ziyin Bu Yang Chinese medicine for sequential treatment. According to the ovulation induction schedule, the patients were divided into 4 groups: group A: clomiphene citrate (CC) + gonadotropin (n = 71); group B: letrozole (LE) : CC (n = 14), group D: Gn (n = 7), and the clinical and laboratory indexes were compared between groups. Results: The pregnancy rates of the four groups were compared: Group C> Group A> Group B> Group D; Gn dosage comparison: Group D> Group B> Group A, thickness of endometrium on day of hCG injection: Group A> Group D> Group B> (P> 0.05). The number of days in promoting group A was significantly higher than that in the other three groups (P <0.05). The ratio of endometrial thickness less than 7 mm in CC group on hCG injection was significantly higher than that in other three groups (P <0.05). There was no significant difference (P> 0.05) in the incidence and non-activation of luteinizing syndrome (LUFS) among the 4 groups, with no OHSS. According to the pregnancy outcome grouping: bE2 and bLH levels of pregnancy group> non-pregnant group, the difference was statistically significant (P <0.05). The thickness of endometrium in pregnancy group was significantly higher than that in non-pregnant group, and the ratio of type A endometrium in each group was significantly higher than that in other types of endometrium. CONCLUSIONS: It is concluded that the sequential therapy combined with CC + Gn can reduce the dosage of Gn, reduce the incidence of ovarian hyperstimulation syndrome (OHSS), increase the thickness of endometrium, improve the endometrial receptivity, Improve pregnancy rate.