伏毛铁棒锤Aconitum flavum Hand-Mazz系我国西北地区民间常用草药,块根为活血为瘀,祛风湿,止痛止血药,其总生物碱部分临床用于多种疾病的疼痛有较好疗效。从中分得二个主要生物碱,鉴定为3-乙酰乌头碱(3-acetylaconitine,Ⅰ)和乌头碱(aconitine,Ⅱ),前者从植物中首次分得,对动物的心脏毒性和急性毒性比乌头碱小,用热板法试验表明,给小白鼠皮下注射3-乙酰乌头碱0.1～0.2mg/kg,有明显的镇痛作用,注射于小 Aconitum flavum Hand-Mazz is a folk herb commonly used in northwestern China. Its roots are blood stasis, rheumatism, and analgesic hemostatic drugs. Its total alkaloids are used clinically for pain in many diseases. Two major alkaloids were isolated from this plant and identified as 3-acetylaconitine (I) and aconitine (II). The former was first isolated from plants and had cardiotoxicity and acute toxicity to animals. Less than aconitine, hot plate test showed that subcutaneous injection of 3-acetylaconitine 0.1 ~ 0.2mg/kg, there is obvious analgesic effect, injection in small