人体的皮肤组成了抵抗外来病原微生物的第一道屏障,其中各种细胞因子和抗菌肽发挥着重要作用,近来发现的一种阳离子小分子多肽——β-防御素-2(hBD-2)是抗菌肽家族的一员。hBD-2主要由上皮细胞产生,广泛存在于皮肤、黏膜上皮组织中,具有广谱的抗菌作用,也有实验表明肿瘤组织中有hBD-2表达,而这些hBD-2有助于机体的抗肿瘤免疫[1],为 Human skin constitutes the first barrier against foreign pathogenic microorganisms, and various cytokines and antimicrobial peptides play an important role. Recently, a small cationic peptide called β-defensin-2 (hBD-2) Is a member of the family of antimicrobial peptides. hBD-2 is mainly produced by epithelial cells, widely exists in the skin and mucosal epithelium, has a broad spectrum of antibacterial activity, and some experiments have shown that hBD-2 is expressed in tumor tissues. These hBD-2s contribute to the anti-tumor Immune [1], for