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本实验在14只麻醉开胸狗心脏上观察了氟碳乳剂与右旋糖酐稀释血液对心肌耗氧量与供应缺血心肌氧量关系的影响。以左室压力-时间指数(SPTI)作为心肌耗氧量的指标,根据冠脉有效侧支血流量(ECF)、PaO_2和 Hb 浓度计算供应缺血心肌的氧量。实验结果表明,低分子右旋糖酐稀释血液后,SPTI 暂时性轻度增加(稀释后30min 时较对照增加7.1±2.7%,P<0.05,稀释后60min 时增加2.8±1.2%,P>0.05),ECF 明显增多(稀释后30min 时较对照增加58.5±6.1%,P<0.01),缺血区边缘心肌氧供需关系未发生明显变化。氟碳乳剂稀释血液后,SPTI 的变化规律与右旋糖酐稀释后相同(稀释后30min 和60min 时分别较对照增加2.5±0.7%和1.9±0.8%)ECF 和 PaO_2升高(稀释后30min 时分别较对照增加53.9±6.7%和93±8.9%),供应缺血心肌的氧量显著增加,缺血区边缘心肌氧供需矛盾明显改善。
In this experiment, the effects of fluorocarbon emulsion and dextran diluted blood on the relationship between myocardial oxygen consumption and supply of ischemic myocardium were observed on the heart of 14 anesthetized open-chest dogs. The left ventricular pressure-time index (SPTI) was used as an indicator of myocardial oxygen consumption, and the oxygen supply to ischemic myocardium was calculated according to the effective coronary artery collateral flow (ECF), PaO 2 and Hb concentrations. The results showed that the SPTI transiently increased slightly after diluted with dextran (7.1 ± 2.7% at 30 min after dilution, P <0.05, 2.8 ± 1.2% at 60 min after dilution, P> 0.05), ECF (Increased by 58.5 ± 6.1% at 30min after dilution, P <0.01). There was no significant change in myocardial oxygen supply and demand in ischemic area. After the blood was diluted with fluorocarbon emulsion, the change rule of SPTI was the same as that of dextran diluted (2.5 ± 0.7% and 1.9 ± 0.8% respectively at 30min and 60min after dilution), while ECF and PaO_2 increased at 30min after dilution 53.9 ± 6.7% and 93 ± 8.9% respectively), the oxygen supply of ischemic myocardium increased significantly, and the contradiction between supply and demand of myocardial oxygen in the marginal zone of ischemic area improved obviously.