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目的··:探讨海洛因依赖恒河猴经用复方中药康赛德治疗后垂体、肾上腺、睾丸等脏器组织结构的恢复情况。方法··:利用光镜对海洛因依赖恒河猴在用康赛德治疗3个月后各脏器的病理学改变进行观察。结果·· :肝细胞变性在自然戒断组为3例 (3/3) ,而康赛德治疗组仅1例 (1/3)。肾上腺的病理改变在自然戒断组和治疗组均为2例 (2/3) ,不过前者病变程度较重 ,大部分皮质束状带细胞水肿 ;而后者仅为个别皮质束状带细胞水肿。睾丸病变在自然戒断组和治疗组也均为2例 (2/3) ,前者曲精细管全部萎缩 ,细胞层次减少 ,无精子形成 ,也未见间质细胞 ,间质内纤维组织增生 ;后者病变程度较轻 ,曲精细管仅是部分萎缩 ,部分管腔内有少数精子 ,可见间质细胞 ,间质内纤维组织轻度增生。附睾及垂体的病理改变在治疗组也较轻。结论··:康赛德治疗 ,可使肾上腺、睾丸、垂体等组织结构和功能尽快地得到恢复
Objective: To investigate the recovery of the structure of pituitary, adrenal gland, testis and other organs in heroin dependent rhesus monkeys treated with compound Chinese medicine Kang Sai De. Methods · · ·: The use of light microscopy of heroin dependent rhesus monkeys treated with Kang Sai De 3 months after the pathological changes were observed. RESULTS: Liver cell degeneration was observed in 3 (3 of 3) patients in the natural withdrawal group and in 1 patient (1 in 3) in the Constellation treatment group. Adrenal pathological changes in the natural withdrawal group and the treatment group were 2 cases (2/3), but the former severe degree of severity, the majority of cortical zonal cell edema; while the latter only for individual cortical zonal cell edema. Testicular lesions in natural withdrawal group and treatment group were also 2 cases (2/3), the former song all the atrophy of the seminiferous tubules, reduced cell levels, no spermatogenesis, nor stromal cells, interstitial fibrosis; The lesser degree of lesion, song is only part of the atrophy of the small tube, part of the lumen a small number of sperm, showing interstitial cells, interstitial fibrosis mild hyperplasia. Epididymal and pituitary pathological changes in the treatment group is also lighter. Conclusions ··: Constellation treatment can make the adrenal gland, testis, pituitary and other organizational structure and function recovered as soon as possible