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家兔在体皮肤苯乙烯(styrene)545.4mg/kg染毒,染毒面积150cm~2,约占家兔体表面积的12％,染毒密度6.98±0.44mg/cm~2,室温25±0.5℃,相对湿度56±5％,风速0.02M/s,家兔皮肤表面温度38.1±0.22℃。用气相色谱法测定血中苯乙烯浓度,并计算毒代动力学参数。其特征如下:1.经皮肤吸收快,Kα=0.7020±0.5268min~(-1),t_(1/2)kα=1.39±0.75min,约6.24min吸收相基本结束。2.吸收程度低,C_(max)=
Rabbits in the body skin of styrene (styrene) 545.4mg / kg of exposure, exposure area of 150cm ~ 2, accounting for about 12% of body surface area of rabbits, exposure density 6.98 ± 0.44mg / cm ~ 2, room temperature 25 ± 0.5 ℃, relative humidity 56 ± 5%, wind speed 0.02M / s, rabbit skin surface temperature 38.1 ± 0.22 ℃. The concentration of styrene in the blood was determined by gas chromatography and the toxicokinetic parameters were calculated. Its characteristics are as follows: 1. Fast absorption through the skin, Kα = 0.7020 ± 0.5268min -1, t 1/2 (1/2) kα = 1.39 ± 0.75min, about 6.24min absorption phase is basically completed. 2. Absorption is low, C_ (max) =