目的　确立视网膜下腔是否具有支持针对视网膜可溶性抗原（Ｓ 抗原） 刺激诱导偏离式免疫反应的能力，并观察白细胞介素１（ＩＬ１） 对视网膜下腔免疫特性的影响。方法　将视网膜Ｓ 抗原接种于Ｗｉｓｔａｒ 大鼠的眼前房和视网膜下腔。抗原接种后７ 天，使用Ｓ 抗原和完全福氏佐剂免疫受主动物。然后，通过足部刺激评估迟发型超敏反应（ ＤＴＨ） 。通过腹腔注射ＩＬ１ 改变全身的免疫状态。结果　前房和视网膜下腔注射Ｓ 抗原的动物没有发生抗原特异性ＤＴＨ。与此相反，当全身给予ＩＬ１ 时，前房和视网膜下腔接种Ｓ 抗原的动物则激发了剧烈的ＤＴＨ。结论　视网膜下腔具有通过抑制抗原特异性ＤＴＨ 支持针对可溶性抗原的免疫偏离的诱导能力。全身使用外源性ＩＬ１ 可以消除视网膜下腔针对局部接种可溶性抗原诱导免疫偏离的能力 Objective To establish whether the subretinal space can support the ability to induce deviant immune responses induced by the stimulation of soluble antigen of the retina (S antigen), and observe the effect of interleukin1 (IL1) on the immunological properties of the subretinal space. Methods Retinal S antigen was inoculated into the anterior chamber and subretinal space of Wistar rats. Seven days after antigen inoculation, recipients were immunized with S antigen and complete Freund’s adjuvant. Delayed hypersensitivity (DTH) was then assessed by foot stimulation. IL 1 by intraperitoneal injection to change the immune status of the body. Results Anterior chamber and subretinal injection of S antigen in animals did not occur antigen-specific DTH. In contrast, animals with S antigen in the anterior chamber and subretinal space elicited vigorous DTH when systemic administration of IL-1. Conclusion The subretinal space has the ability to induce immunity against soluble antigens by inhibiting antigen-specific DTH support. The systemic use of exogenous IL 1 can eliminate subretinal local immunization with soluble antigen-induced immune deviation ability