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我们应用选择性α_1-受体激动剂新福林灌注时,门脉压、嵌塞肝静脉压明显上升,其血管阻力相应增加,先用选择性α_1-受体拮抗剂哌唑嗪灌注10分钟后,再用新福林,则门脉压、嵌塞肝静脉及门脉血管阻力均无明显变化,提示哌唑嗪能完全阻断新福林对门脉血管床的作用。应用选择性α_2-受体激动剂可乐定及其拮抗剂进行同样实验,观察到可乐定对门脉压、嵌塞肝静脉压及门脉血管阻力均无明显影响。去甲肾上腺素为混合性α-受体(含有α_1-及α_2-受体)的激动
We use selective alpha 1 -receptor agonist perfusion, portal pressure, impaired hepatic venous pressure increased significantly, the vascular resistance corresponding increase, with a selective alpha 1 -receptor antagonist prazosin perfusion for 10 minutes After the new Fulin, then portal pressure, impacted hepatic vein and portal vein resistance were no significant changes, suggesting that prazosin can completely block the new Fulin on the portal vein bed. The same experiment with clonidine and its antagonist, a selective α 2 -agonist agonist, showed no significant effect of clonidine on portal pressure, impaired hepatic venous pressure and portal vascular resistance. Norepinephrine is a mixed agonist of alpha -receptors (which contain alpha 1 -and alpha 2 -receptors)