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西沙必利在治疗一些肠道推进功能障碍的疾病上有益处。研究旨在比较西沙必利和安慰剂对IBS伴便秘病人症状上的作用。 方法:70名18～75岁IBS伴便秘的门诊病人,症状持续或反复发作6个月以上,1周至少发作3次,并且以往治疗不满意。IBS便秘定义为:①腹痛在排便后缓解或伴有大便次数和性状改变;②便秘(至少符合下列2个条件):a.1周排便少于3天;b.硬便;c.排便习惯改变(费力、紧迫感或排便不尽感);d.排粘液;③腹胀或腹部膨隆。采用随机、双盲、配对方法,入选前询问详细病史并作直乙结肠镜检查,治疗前后作体检及实验室检查。40岁以上有症状的病人在近6个月内接受过
Cisapride has been shown to be beneficial in the treatment of some diseases of gut dysfunction. The aim of the study was to compare the effects of cisapride and placebo on the symptoms of IBS with constipation. METHODS: Seventy outpatients with constipation of 18 to 75 years old with IBS who had persistent or recurrent symptoms for more than 6 months were challenged with at least 3 episodes per week and were dissatisfied with previous treatment. IBS constipation is defined as: ① abdominal pain relief after bowel movement or accompanied by changes in stool frequency and traits; ② constipation (at least meet the following two conditions): a.1 week defecation less than 3 days; b. Hard; c bowel habits Change (effort, urgency or defecation endless feeling); d. Mucus; ③ bloating or bulging abdomen. A randomized, double-blind, matching method, prior to the election asked for a detailed history and for direct B colonoscopy, before and after treatment for physical examination and laboratory tests. Symptomatic patients over the age of 40 received in the past 6 months