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夏天无总碱(COAMTA)系从伏生紫堇之块茎中分离出的有效成分。动物实验表明,COAMTA具有明显抑制血小板聚集、抑制血栓形成等作用。本文观察了COAMTA对家兔血小板内cAMP和cGMP含量的影响。结果0.08—0.16mg/ml PRP的COAMTA可明显提高血小板内cAMP含量;剂量为0.16mg/ml PRP还可使cGMP含量升高,但cAMP/cGMP的比值增加更为明显,提示COAMTA主要是通过影响cAMP含量而发挥抑制血小板功能的作用。
Summer total alkaloids (COAMTA) is the active ingredient isolated from the tubers of Volatile Corydalis. Animal experiments show that COAMTA has a significant inhibition of platelet aggregation, inhibition of thrombosis and other effects. In this paper, the effects of COAMTA on the contents of cAMP and cGMP in rabbit platelets were observed. Results COAMTA of 0.08-0.16mg / ml PRP could significantly increase the content of cAMP in platelets. The dose of 0.16mg / ml PRP also increased the content of cGMP, but the ratio of cAMP / cGMP increased more obviously, which indicated that COAMTA was mainly affected by cAMP content and play a role in inhibiting platelet function.