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目的:探讨高铁蛋白血症与糖尿病及糖尿病肾病的关系。方法:分别用放射免疫法和酶联免疫法测定96例糖尿病患者及20例正常对照组血清铁蛋白、尿白蛋白。结果:①糖尿病患者血清铁蛋白水平较正常对照组明显升高。②高铁蛋白血症组24小时尿白蛋白排泄(24hruAE)增高的发生率较正常血清铁蛋白组明显升高。③血清铁蛋白增高的发生率随尿白蛋白排泄增加而增高;正常、微量及大量白蛋白尿患者,其血清铁蛋白增高率分别为26.3%、41.9%及87.5%。结论:高铁蛋白血症与糖尿病及糖尿病肾病关系密切
Objective: To investigate the relationship between hyperfercemia and diabetic and diabetic nephropathy. Methods: Serum ferritin and urinary albumin were detected in 96 diabetic patients and 20 normal controls by radioimmunoassay and enzyme-linked immunosorbent assay respectively. Results: ① The level of serum ferritin in diabetic patients was significantly higher than that in normal controls. ② The incidence of 24-hour urinary albumin excretion (24hruAE) increased significantly in patients with high-ferritin group compared with the normal serum ferritin group. (3) The incidence of serum ferritin increased with the increase of urinary albumin excretion. The increase rates of serum ferritin were 26.3%, 41.9% and 87.5% respectively in patients with normal, micro and large amounts of albuminuria. Conclusion: Hyperohllinemia is closely related to diabetes and diabetic nephropathy