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Calcium homeostasis in synaptosomes is altered during aging. The intrasynaptomal free calcium concentration ([Ca2+]i) was determined in 3- and 24-month-old rats treated with or without Rbl and Rgl. As expected, the [Ca2-]i level increased with age. Treatment with Rbl and Rgl elicited an obvious decrease of [Ca2+]i content, especially in aged rates. In addition, Rbl and Rgl significantly stimulated the activity of Na+, K+-ATPase while Rbl inhibited the activity of Ca2+, Mg2--ATPase arid calmodulin. In view of the close relationship of [Ca2-]i level with aging, the changes of [Ca2+]i induced by Rbl and Rgl, as shown by our results, might provide an explanation of the mechanisms of their antiaging function.
The intrasynaptomal free calcium concentration ([Ca2 +] i) was determined in 3- and 24-month-old rats treated with or without Rbl and Rgl. As expected, the [Ca2-] i level Rbl and Rgl significantly stimulated the activity of Na +, K + -ATPase while Rbl inhibited the activity of Ca2 +, Mg2 - ATPase arid calmodulin. In view of the close relationship of [Ca2-] i level with aging, the changes of [Ca2 +] i by Rbl and Rgl, as shown by our results, might provide an explanation of the mechanisms of their antiaging function.