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目的了解阿托伐他汀对高脂血症患者血脂的影响,同时探讨阿托伐他汀的其他临床应用。方法回顾性分析70例贵阳市第一人民医院老干部门诊及金阳门诊高脂血症患者2009年至2011年的血脂变化情况。结果阿托伐他汀组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)明显下降,差异有统计学意义(P>0.05);高密度脂蛋白(HDL-C)明显升高,差异有统计学意义(P>0.05)。结论阿托伐他汀有效降低患者TG、TC、LDL-C的水平,有效升高HDL-C的水平。阿托伐他汀同时具有以下作用:①抗动脉粥样硬化;②调节血管内皮功能、稳定斑块、抑制炎症反应和血管平滑肌增殖,减少急性冠状动脉综合征及脑卒中的发生率;③轻度调节血压;④治疗糖尿病肾病;⑤防治骨折。
Objective To investigate the effect of atorvastatin on blood lipids in patients with hyperlipidemia and to explore other clinical applications of atorvastatin. Methods A retrospective analysis of 70 cases of Guiyang First People’s Hospital veteran clinics and Jinyang outpatient hyperlipidemia in 2009 to 2011, the changes of blood lipids. Results The levels of triglyceride (TG), total cholesterol (TC) and low density lipoprotein (LDL-C) in Atorvastatin group were significantly decreased (P> 0.05) ) Was significantly higher, the difference was statistically significant (P> 0.05). Conclusions Atorvastatin can effectively reduce the level of TG, TC and LDL-C in patients and effectively increase the level of HDL-C. Atorvastatin also has the following effects: ① anti-atherosclerotic; ② regulate endothelial function, stabilize the plaque, inhibit inflammation and vascular smooth muscle proliferation, reduce the incidence of acute coronary syndrome and stroke; ③ mild Regulate blood pressure; ④ treat diabetic nephropathy; ⑤ prevent fractures.