Myelinated axons of the peripheral and central nervous system(PNS&CNS)are divided into molecularly distinct excitable domains,including the axon initial segment(AIS)and nodes of Ranvier.The AIS is composed of a dense network of cytoskeletal proteins,cell adhesion molecules,and voltage gated ion channels and is located at the proximal most region of the axon(Kole Myelinated axons of the peripheral and central nervous system (PNS & CNS) are divided into molecularly distinct excitable domains, including the axon initial segment (AIS) and nodes of Ranvier. The AIS is composed of a dense network of cytoskeletal proteins, cell adhesion molecules, and voltage gated ion channels and is located at the proximal most region of the axon (Kole