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目的探讨明矾对大鼠脑组织中单胺氧化酶(MAO)活力、乙酰胆碱酯酶(AChE)活力及乙酰胆碱(ACh)含量的影响。方法 32只Wistar大鼠,随机分为对照组、低、中、高剂量组4组,低、中、高剂量组大鼠饲料中分别加入明矾1457、2914、4371mg/kg,染毒30d,测定大鼠脑组织中MAO活力、AChE活力及ACh含量。结果随着饲喂明矾量的增加,各剂量组大鼠脑系数逐渐升高,中、高剂量组脑系数高于对照组(P<0.01);高剂量组MAO活力高于对照组(P<0.05),低、中剂量组与对照组比较差异无统计学意义(P>0.05);各剂量组大鼠脑组织中AChE活力呈上升趋势,中、高剂量组高于对照组(P<0.01);中、高剂量组ACh含量低于对照组(P<0.01)。结论明矾的摄入在一定程度上影响大鼠脑组织中MAO、AChE活力及ACh含量,损伤大鼠脑神经系统。
Objective To investigate the effects of alum on monoamine oxidase (MAO) activity, acetylcholinesterase (AChE) activity and acetylcholine (ACh) content in rat brain. Methods Thirty-two Wistar rats were randomly divided into control group, low, medium and high dose groups of 4, low, medium and high doses of rats were fed alum 1457,2914,4371mg / kg, exposure to 30d, MAO activity, AChE activity and ACh content in rat brain tissue. Results With the increase of the amount of alum, the cerebral coefficient of rats in each dose group increased gradually, and the cerebral coefficient of middle and high dose group was higher than that of control group (P <0.01). The MAO activity of high dose group was higher than that of control group (P < 0.05). There was no significant difference between the low and middle dose groups and the control group (P> 0.05). The AChE activity in the brain tissue of each dose group showed an upward trend, while the middle and high dose groups were higher than the control group (P <0.01) ); Middle and high dose group ACh content was lower than the control group (P <0.01). Conclusion Alum uptake may affect MAO, AChE activity and ACh content in rat brain tissue to a certain extent, and injure rat brain system.