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1980年10月在我国黄淮平原间日疟流行区。分别以单用氯喹1.5g的三天疗法和氯喹合并伯喹112.5mg的五天疗法治疗82例及145例间日疟现症病人,追踪观察至次年7月,复发率分别为45.1％和15.2％,平均每人复发次数分别为1.4次和1.1次,多次复发者均为儿童。两组均未见8周内的近期复发,复发均集中出现于次年5月和6月。间接荧光抗体试验表明两组病例的抗体水平变化与复发情况相符。两组的累计抗体滴度和抗体阳性率(≥1:80)均有极显著差异,与用镜检法得到的两组复发率的显著性检验结果一致,提示IFA用于比较不同疗法的效果有参考价值。
1980 October in China Huanghuai plain vivax region. Eighty-one cases and 145 cases of V.vipoensis were treated with three-day treatment of chloroquine 1.5g and five-day treatment of 112.5mg of chloroquine together with primaquine respectively. The follow-up was observed till the following July. The recurrence rates were 45.1% and 15.2%, the average number of recurrences per person were 1.4 times and 1.1 times, multiple relapse were children. No recurrences were found in either group within 8 weeks, with recurrence occurring in May and June of the following year. Indirect fluorescent antibody tests showed that the antibody levels in both groups matched the relapse. The cumulative antibody titers and antibody positive rates (≥1: 80) were significantly different between the two groups, which were in good agreement with those of the two groups with microscopic examination, suggesting that IFA was used to compare the effects of different therapies A reference value.