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本文采用流式细胞术（ＦＣＭ）研究了Ｂｃｌ－２蛋白在大肠癌中的表达。结果显示肿瘤的Ｂｃｌ－２蛋白表达量（１．３１±０．４１）明显高于正常粘膜细胞（１．０±０．１５），Ｐ＜０．００１；粘液腺癌、腺棘细胞癌和低分化腺癌的Ｂｃｌ－２蛋白表达量（１．４５±０．２１）高于中分化腺癌（１．３１±０．２２），Ｐ＜０．０５；低分化腺癌的Ｂｃｌ－２蛋白表达量（１．４８±０．０８），高于中、高分化腺癌（１．３１±０．２２），Ｐ＜０．０５；浸润型肿瘤的Ｂｃｌ－２蛋白表达量（１．４４±０．２０），高于非浸润型肿瘤（１．３０±０．２２），Ｐ＜０．０２５；异倍体肿瘤的Ｂｃｌ－２蛋白表达量（１．４１±０．２０），高于二倍体肿瘤（１．２４±０．２２），Ｐ＜０．０２５。因此认为，Ｂｃｌ－２蛋白与大肠癌的形成和不良预后相关。
Flow cytometry (FCM) was used to study the expression of Bcl-2 protein in colorectal cancer. The results showed that the expression of Bcl-2 protein in the tumor (1.31±0.41) was significantly higher than that in the normal mucosal cells (1.0±0.15), P<0.001; mucinous adenocarcinoma, adenosquamous cell carcinoma, and The expression of Bcl-2 protein in poorly differentiated adenocarcinoma (1.45±0.21) was higher than that in moderately differentiated adenocarcinoma (1.31±0.22), P<0.05; Bcl-2 in poorly differentiated adenocarcinoma The protein expression level (1.48±0.08) was higher than that of moderately-differentiated adenocarcinoma (1.31±0.22), P<0.05; the expression of Bcl-2 protein in infiltrating tumors (1. 44±0.20), higher than non-invasive tumors (1.30±0.22), P<0.025; Bcl-2 protein expression of aneuploid tumors (1.41±0.20), Higher than diploid tumors (1.24±0.22), P<0.025. Therefore, it is believed that Bcl-2 protein is associated with the formation and poor prognosis of colorectal cancer.