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目的观察螺内酯对高血压病患者血管内皮功能的影响及其降压治疗效果。方法60例高血压病患者随机分为二组常规治疗组30例,采用非洛地平、培多普利治疗4w;螺内酯治疗组30例,在非洛地平、培多普利治疗基础上加用螺内酯联合治疗4w,观察二组血清一氧化氮(NO)和过氧化氢酶(CAT)的改变及降压效果。结果经上述治疗后,二组高血压患者的血清NO及CAT均有升高,血压亦明显下降,其中,以螺内酯治疗组NO、CAT升高更为显著(P<0.01),降压幅度更加明显(P<0.05)。结论高血压患者采用螺内酯联合治疗,可能更有利于改善患者的血管内皮功能,增强降压效果。
Objective To observe the effect of spironolactone on the vascular endothelial function in patients with essential hypertension and the effect of antihypertensive treatment. Methods Sixty patients with essential hypertension were randomly divided into two groups: conventional treatment group (30 cases), felodipine and pendipril treatment (4 weeks), spironolactone treatment group (n = 30), and felodipine and Spironolactone combination treatment 4w, observed two groups of serum nitric oxide (NO) and catalase (CAT) changes and antihypertensive effect. Results After the above treatment, serum NO and CAT were elevated and blood pressure was significantly decreased in both groups. Among them, NO and CAT increased more significantly (P <0.01) Obviously (P <0.05). Conclusions The combination therapy of spironolactone in hypertensive patients may be more beneficial to improve the vascular endothelial function and enhance the antihypertensive efficacy.