结缔组织病是风湿性疾病中的一大类,属非器官特异性的自身免疫疾病,可累及单个或多个系统出现不同的临床表现。其机制目前尚不明确,多数研究表明与自身抗体及T细胞介导有关,以血管和结缔组织的慢性炎症为病理基础。结缔组织病可累及大脑、脑膜、脊髓、颅神经及神经末梢等神经系统,有多种临床表现。多数结缔组织病经皮质类固醇及免疫抑制剂治疗后有效,但症状多不能完全缓解,新的治疗方案仍有待进一步研究。 Connective tissue disease is a major category of rheumatic diseases and is a non-organ-specific autoimmune disease that can involve different clinical manifestations of single or multiple systems. The mechanism is not yet clear, the majority of studies have shown that with autoantibodies and T cell-mediated, with vascular and connective tissue chronic inflammation as the pathological basis. Connective tissue disease can affect the brain, meninges, spinal cord, cranial nerve and nerve endings and other nervous systems, a variety of clinical manifestations. Most of the connective tissue disease after corticosteroid and immunosuppressive therapy effective, but the symptoms can not be completely relieved, the new treatment remains to be further studied.