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目的:探讨三仁汤加味联合抗反转录病毒(HAART)疗法在艾滋病前期防治中的临床疗效。方法:选取2013年9月至2014年12月期间我院收治的60例符合中医辨证湿热内蕴型艾滋病前期患者作为本组研究的观察对象,随机将其分为对照组与试验组各30例,对照组给予单纯HAART治疗,试验组在HAART治疗的基础上加用三仁汤加味治疗,分别于观察起点与治疗6个月时对比2组患者的临床疗效及症状体征积分、卡洛夫斯基积分及CD4+T淋巴细胞计数,并分析三仁汤加味联合HAART疗法的有效性与安全性。结果:(1)治疗6个月后,2组的症状体征积分均有所下降,试验组有效16例,稳定9例,无效5例,总有效率为83.33%;对照组有效11例,稳定7例,无效12例,总有效率为60%,试验组明显高于对照组,具有统计学意义(P<0.05)。(2)观察起点,2组患者的卡洛夫斯基积分及CD4+T淋巴细胞计数之间无明显差异,不具有统计学意义,P>0.05;治疗6个月后,试验组的卡洛夫斯基积分及CD4+T淋巴细胞计数明显增高,均具有统计学意义,P<0.05。结论:三仁汤加味联合HAART疗法可改善艾滋病前期患者的湿热症状和体征,提高生存质量,安全性较好,值得在临床中推广应用。
Objective: To investigate the clinical effect of Sanren Decoction combined antiretroviral (HAART) therapy in the prevention and treatment of AIDS. Methods: From September 2013 to December 2014 in our hospital admitted to 60 cases of traditional Chinese medicine syndrome differentiation of damp-heat type of AIDS patients as the object of this study, were randomly divided into control group and test group of 30 cases , The control group was treated with HAART alone. The experimental group was treated with Sanren Decoction on the basis of HAART, and the clinical efficacy and symptom and symptom scores of the two groups were compared between the beginning of observation and the 6 months of treatment. Basal integration and CD4 + T lymphocyte count, and analyze the effectiveness and safety of San Ren Tang plus HAART therapy. Results: (1) Six months after treatment, the scores of symptom and symptom in both groups decreased. In the experimental group, 16 cases were effective, 9 cases were stable, 5 cases were ineffective and the total effective rate was 83.33%. In the control group, 11 cases were effective and stable 7 cases, 12 cases were ineffective, the total effective rate was 60%, the experimental group was significantly higher than the control group, with statistical significance (P <0.05). (2) The starting point of observation, there was no significant difference between the two groups of patients with Karovski’s score and CD4 + T lymphocyte count, there was no statistical significance, P> 0.05; after 6 months of treatment, Fusky score and CD4 + T lymphocyte count were significantly increased, both of which were statistically significant (P <0.05). Conclusion: Sanren decoction combined with HAART therapy can improve the symptoms and signs of damp-heat in pre-AIDS patients, improve the quality of life, and have better safety. It is worth to be popularized in clinic.