作者首例报导初次应用甲氰咪胍后发生严重急性肾功能衰竭并经活检证实为急性间质性肾炎的患者。停药后肾功能明显改善。 67岁,白人男性,因发热、寒颤、乏力和食欲不振二周入院。在前6年中因局限性肠炎而用柳氮磺胺吡啶(1克/日)和强的松(5mg/日)治疗,入院时病情稳定。本次症状发作前3周,患者开始用甲氰咪胍(900mg/日)来治疗长期类固醇疗法有关的功能性上胃肠道症状。入院时已停用柳氮磺胺吡啶。体检无特殊。血尿素氮34mg％,血清肌酐2.4mg％,周围血白细胞数16200、核左移、嗜酸粒细胞6％。尿检 The authors report the first case of acute acute renal failure after initial application of cimetidine and confirmed by biopsy as acute interstitial nephritis. After stopping the renal function improved significantly. 67 years old, white male, hospitalized for fever, shivering, weakness, and loss of appetite for two weeks. Sulfasalazine (1 g / day) and prednisone (5 mg / day) were treated for localized enteritis in the first 6 years and were stable on admission. Three weeks prior to the onset of this symptom, patients started treatment of functional gastrointestinal symptoms associated with long-term steroid therapy with cimetidine (900 mg / day). Sulfasalazine has been discontinued at admission. No special medical examination. Blood urea nitrogen 34mg%, serum creatinine 2.4mg%, the number of peripheral blood leukocytes 16200, left nuclear shift, eosinophils 6%. Urinalysis