至今,血管性假血友病(vWD)的患病率多根据血友病中心的登记病例数估计,本文报告意大利北部两个区的1 218名中学生的流行病学调查结果。调查步骤大致如下:①选定意大利北部距Vicen-za 30与40公里的两个相互无联系的地区,1218名11—14岁的中学生为调查对象;(2)对调查对象及其上三代亲属(父、母双方)以调查表方式了解出血症状:鼻衄,拔牙后出血,手术后出血,皮肤割破或产后出血,月经过多,易出血等;(3)对出血症状充分核实,排除轻微的、非真正出血的症状及继发于其它疾病的出血;(4)对疑有出血史的家庭进一步访问,详细了解家庭成员及有关亲属的出血情况;(5)根据调查表及访问结果确定可能的阳性对象及阴性家族:至少有两项出血症状的人为可能的阴性对象;至 To date, the prevalence of von Willebrand disease (vWD) is mostly based on the number of registered cases in the hemophilia center. This paper reports on the epidemiological findings of 1 218 middle school students in two districts of northern Italy. The investigation steps are as follows: (1) 1218 middle school students aged 11-14 years were selected as survey subjects in two unrelated regions between Vicenza 30 and 40 km in the northern part of Italy; (2) (Both parents and parents) to understand the symptoms of bleeding in the form of a questionnaire: epistaxis, bleeding after tooth extraction, bleeding after surgery, skin incision or postpartum hemorrhage, menorrhagia, bleeding easily; (3) full verification of bleeding symptoms Minor, non-real bleeding symptoms and bleeding secondary to other diseases; (4) further visits to families suspected of having a history of bleeding to learn more about the bleeding of family members and relatives; (5) based on the questionnaire and interview results Identify potential positive subjects and negative families: Man-made possible negative subjects with at least two bleeding symptoms;