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某些脊髓发育不良综合征或急性非淋巴细胞白血病病人骨髓有丝分裂中的全部或部分第七对染色体单体与粒细胞功能缺陷有关。为了研究哪些组血细胞系受此单体的影响,研究人员用特异性第七对染色体DNA探针对从5名病人血液中分离出的特定细胞碎片的DNA进行了DNA印迹法实验。通过判断限制性片段长度的多形性有无两种不同的的等位基因,发现所有5名病人的淋巴细胞都有两个不同的第七对染色体。4名病人(第
In some cases of myelodysplastic syndrome or acute non-lymphocytic leukemia, all or part of the chromosome 7 in myeloid mitosis is associated with defective granulocyte function. In order to investigate which group of blood cell lines are affected by this monomer, the researchers used a specific pair of chromosomal DNA probes to perform Southern blotting on DNA from specific cell fragments isolated from the blood of five patients. By determining whether the polymorphism in the length of the restriction fragment has two different alleles, all five patients’ lymphocytes were found to have two distinct seventh pairs of chromosomes. 4 patients (No.