本文综述了阿片肽药理研究中应用重组DNA 技术所取得的一些成果。现已发现多巴胺能药物、糖皮质激素、应激和吗啡等对阿片肽基因的表达具有调节作用,而且都发生在转录水平上。这种药物的调节作用究竟是促进阿片肽mRNA的生物合成还是抑制其降解,尚不明了;但却有助于对阿片肽转换率(turnover)变化的理解。 This review summarizes some of the results achieved with recombinant DNA technology in opioid pharmacological studies. It has been found that dopaminergic drugs, glucocorticoids, stress and morphine have a regulatory effect on opioid peptide gene expression, and both occur at the transcriptional level. Whether the regulation of this drug promotes opioid peptide biosynthesis or inhibits its degradation is unclear; however, it helps to understand the change in opioid turnover.