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本研究应用烟酸诱激人体恶性疟原虫,提高了血液涂片中的原虫数和阳性检出率。对34例恶性疟原虫阳性患者分别于服烟酸前和服烟酸后15、30、60、120和180min 耳垂采血检查,作原虫计数,服烟酸后分别比服烟酸前增加8.0%、26.6%、68.6%、68.1%和48.0%。镜检阴性的48例疑似病人,经诱激后转为阳性的11例。仍为阴性的37例,经随访15d,均未有临床发作,血检仍为阴性。普查581人,服烟酸后阳性检出率比未服烟酸前多检出14例,阳性检出率提高24%。适宜的烟酸剂量成人为200mg,服后60min 左右时采血为宜。
In this study, nicotinic acid was used to induce human Plasmodium falciparum, which increased the number of protozoa in blood smear and the positive detection rate. 34 cases of Plasmodium falciparum positive patients before and after taking nicotinic acid and niacin at 15, 30, 60, 120 and 180min lobeloar blood test for protozoa count, respectively, after taking nicotinic acid, nicotinic acid were increased by 8.0%, 26.6 %, 68.6%, 68.1% and 48.0%. 48 cases of suspected negative patients with microscopy, after induction of positive turned to 11 cases. 37 cases were still negative, the follow-up 15d, no clinical seizures, blood tests are still negative. Census 581 people, after taking nicotinic acid positive detection rate than before without nicotinic acid were detected in 14 cases, the positive detection rate increased by 24%. The appropriate dose of niacin for adults 200mg, about 60min after taking blood appropriate.