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通过动物实验观察到益肝康冲剂能有效阻止复合因素所致大鼠慢性肝损害及肝硬化的形成。益肝康冲剂能显著降低实验大鼠死亡率,降低酶活性水平(ALT:38.6±9.2u/L,AST:41.4±9.0u/L)能显著提高血清白蛋白(ALB)水平(36.1±2.5g/L),能降低肝羟脯氨酸(Hyp)水平(14.96±1.9μg/mg),能改善肝脏病理损害,与病理对照组、乙肝宁和秋水仙碱治疗组比较,均有显著性差异,P<0.05。
Through animal experiments, it was observed that Yigankang Granules can effectively prevent the formation of chronic liver damage and cirrhosis caused by compound factors in rats. Yigankang Granules can significantly reduce the mortality rate of experimental rats. Decreasing the level of enzyme activity (ALT: 38.6±9.2u/L, AST: 41.4±9.0u/L) can significantly increase the level of serum albumin (ALB) (36.1±2.5). g/L) can reduce the level of hepatic hydroxyproline (Hyp) (14.96±1.9μg/mg) and improve liver pathological lesions. It is significant compared with the pathological control group, Yiganing and colchicine groups. Difference, P<0.05.