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目的研究北京地区RhD阴性献血人群中Rh表型的分布情况及不同表型与D变异型的相关性。方法用间接抗球方法(IAT)确认检验科初筛RHD阴性个体的Rh(D)血型,用血型分型卡确定Rh系统表型。结果 3795例初筛阴性标本中ccee 2139例(56.36%)、Ccee 1045例(27.54%)、ccEe 334例(8.80%)、CCee 157例(4.14%)、Cc Ee 106例(2.79%)、ccEE 12例(0.32%)、CCEe 2例(0.05%);其中D变异型144例,各表型D变异型例数及占各自总数的比例为ccee 6例(0.28%)、Ccee 21例(2.01%)、ccEe 92例(27.54%)、CCee 14例(8.91%)、Cc Ee 9例(8.49%)、ccEE 2例(16.67%),CCEe 0例。结论北京市RhD阴性献血者以ccee为主,含有E抗原的初筛Rh阴性个体为D变异型的可能性高于其他表型的个体。
Objective To investigate the distribution of Rh phenotypes in RhD-negative blood donors in Beijing and the correlation between different phenotypes and D variants. Methods The Rh (D) blood group of RHD-negative individuals was screened by indirect anti-ball method (IAT), and the phenotype of Rh system was determined by blood typing card. Results There were 2139 cases (56.36%) of ccee, 1045 cases (27.54%) of Ccee, 334 cases (8.80%) of ccEe, 157 cases (4.14%) of CCee, 106 cases (2.79%) of CeEe, 12 cases (0.32%) and 2 cases of CCEe (0.05%). There were 144 cases of D variant and 6 cases of Ccee (0.28%) and 21 cases of Ccee (2.01 There were 92 cases of ccEe (27.54%), 14 cases of CCee (8.91%), 9 cases of Ce Ee (8.49%), 2 cases of ccEE (16.67%) and 0 cases of CCEe. Conclusion In Beijing, RhD-negative blood donors are predominantly ccee, while Rh-negative individuals with E-antigen are more likely to be D mutants than those with other phenotypes.