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近年来曾有报道促黄体生成激素释放激素(LH-RH)和具有过度刺激活性的类似药物在实验动物和人类对生殖功能有反常性抑制。每天给予强效的 LH-RH 促效剂可以抑制妇女排卵。这种控制生育的新方法经过短期临床研究证明是安全和有效的。目前进行的是长期使用 LH-RH 促效剂抑制排卵的研究,51名健康妇女使用超活性的 LH-RH 促效剂 D-Ser(TBU)~6-EA~(10)-LH-RH,3～12个月。发现鼻内给药是一种实用的,安全的,有效的而且也是迅速可逆的避孕方法。51名月经正常妇女,年龄19～39岁(平均28.6岁),志愿参加研
In recent years, it has been reported that luteinizing hormone-releasing hormone (LH-RH) and similar drugs with excessive stimulating activity have abnormally suppressed reproductive function in experimental animals and humans. A daily potent LH-RH agonist inhibits ovulation in women. This new method of fertility control proved to be safe and effective after short-term clinical studies. At present, long-term LH-RH agonist is used to inhibit ovulation. Fifty-one healthy women use hyperoxic LH-RH agonist D-Ser (TBU) 3 to 12 months. Intranasal administration was found to be a practical, safe, effective and rapidly reversible method of contraception. 51 normal menstruating women, aged 19 to 39 years (mean 28.6 years), volunteer to participate in research