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目的:探讨当归芍药散配伍对主要入血成分药动学的影响规律。方法:将当归芍药散分为白芍组(S)、归-芎组(DC)、芍-归-芎组(SDC)和全方组(DSS)。大鼠分别灌胃各组提取物,采用HPLC测定血浆中芍药内酯苷、芍药苷、阿魏酸和藁本内酯的含量,计算并比较各组药动学参数。结果:归-芎组与白芍配伍后使芍药苷和芍药内酯苷出现了多重吸收的过程,全方组中多重吸收现象消失,Tmax和MRT缩短,AUC降低。白芍与归-芎组配伍降低了阿魏酸的Cmax,Tmax,MRT和AUC,全方组较芍-归-芎组除AUC提高外无明显区别。白芍降低了归-芎组藁本内酯Cmax和AUC,与芍-归-芎组相比,全方组的MRT缩短,AUC增加。结论:方中臣药归-芎对君药白芍成分的影响体现在多重吸收的现象,君药对臣药成分的影响为显著降低血药浓度水平和生物利用度。佐使药对芍-归-芎组中君药成分影响较大,使其消除速度加快,生物利用度降低。
Objective: To investigate the effect of compatibility of Danggui Shaoyao San on the pharmacokinetics of major components of blood. Methods: The Danggui Shaoyao San was divided into the group of Radix Paeoniae Alba, Scutellaria barbata DC, SDC and DSS. The rats were respectively gavaged with the extracts of each group. The contents of paeoniflorin, paeoniflorin, ferulic acid and ligustilide in plasma were determined by HPLC, and the pharmacokinetic parameters were calculated and compared. Results: Paeoniflorin and paeoniflorin appeared multiple absorption after the combination of Guizhixiong and Paeoniae Radix Paeoniae Alba, the phenomenon of multiple absorption disappeared in all groups, Tmax and MRT were shortened and AUC was decreased. Radix Paeoniae Alba and Guizhi - Xiongxiao group decreased the Cmax, Tmax, MRT and AUC of ferulic acid. There was no significant difference between the whole group and Shao-Gui-Xiongxiong group except AUC. Radix Paeoniae Alba reduced ligustilide Cmax and AUC, compared with the Shaoyao - Ligusticum group, the whole group of MRT shortened, AUC increased. CONCLUSION: The effect of Fangzhongchenyao-Ligusticum on the components of Radix Paeoniae alba is reflected in the phenomenon of multiple absorption. The effect of the monarch on the composition of the herbs is to significantly reduce the plasma concentration and bioavailability. Adjuvant drug on the Shaoyao - Ligusticum Jun medicine composition of a greater impact, so that the elimination of speed, bioavailability decreased.