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目的 观察尿激酶治疗糖尿病性周围神经病变的疗效。方法 4 6例糖尿病性周围神经病变患者 ,随机分为两组 ,2 4例用尿激酶治疗 (治疗组 ) ,2 2例用复方丹参注射液治疗 (对照组 )。结果 治疗组与对照组显效率有显著性差异 (P <0 .0 1) ,而总有效率无显著性差异 (P >0 .0 5)。患者治疗后生化指标的变化比较 ,胆固醇变化无显著性差异 (P >0 .0 5) ,而甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇与空腹血糖的变化均差异显著 (分别为P <0 .0 1,P <0 .0 5,P <0 .0 5,P <0 .0 1)。结论 尿激酶不仅对改善糖尿病性周围神经病变 ,降低血脂和血糖有疗效 ,而且未见副作用 ,是值得临床上继续探索和应用的一种方法
Objective To observe the therapeutic effect of urokinase on diabetic peripheral neuropathy. Methods Twenty-six patients with diabetic peripheral neuropathy were randomly divided into two groups, 24 patients treated with urokinase (treatment group) and 22 patients treated with compound salvia miltiorrhiza injection (control group). Results There was significant difference between the treatment group and the control group (P <0.01), but the total effective rate was not significantly different (P> 0.05). There was no significant difference in the change of biochemical indexes after treatment between the two groups (P> 0.05), while the changes of triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol and fasting blood glucose were significantly different P <0. 01, P <0. 05, P <0. 05, P <0 1. Conclusions Urokinase is not only effective in improving diabetic peripheral neuropathy, lowering blood fat and blood sugar, but also has no side effects, which is worth to be explored and applied clinically