目的　探讨被动转移东方田鼠血清抗日本血吸虫感染力及其作用机理。　方法　将东方田鼠血清通过尾静脉注射途径被动转移至小鼠 ,观察攻击感染日本血吸虫尾蚴后的减虫率、减卵率 ,并采用ELISA分别检测抗日本血吸虫童虫、成虫和虫卵的 8种抗体。　结果　与生理盐水对照组比较 ,东方田鼠血清受体小鼠获得的减虫率为 3 6.2 % ,减卵率为 5 4.0 % ;血清IgE、IgM、IgG及其亚类抗体均有升高 ,其中抗童虫抗原的IgG1抗体水平增幅最大。各试验组小鼠血清抗体水平差异均无显著性 (P >0 .0 5 )。　结论　东方田鼠抗日本血吸虫感染的天然抵抗力可通过血清被动转移至小鼠 ,使之获得部分抗血吸虫感染的保护力 ,该保护力可能是通过同时诱导受体小鼠Th1和Th2型免疫应答发挥作用的 Objective To investigate the anti-Japanese infection of Schistosoma japonicum by passive transfer of Microtus fortis and its mechanism. Methods The voles of Microtus fortis were passively transferred to the mice via tail vein injection and the worm reduction rate and the oviposition rate of the infected Schistosoma japonicum cercariae were observed. ELISA was used to detect 8 species of schistosomula, antibody. Results Compared with the saline control group, the worm reduction rate of voles received in mice was 32.2% and the rate of egg reduction was 5.04%. Serum IgE, IgM, IgG and its subclasses were all increased IgG1 antibody levels increased the most for anti-parasitism antigens. There was no significant difference in the level of serum antibody in each experimental group (P> 0.05). CONCLUSIONS: The natural resistance of Microtus fortis against Schistosoma japonicum infection can be passively transferred to mice via sera to obtain partial protection against schistosomiasis, which may be exerted by both inducing Th1 and Th2 immune responses in recipient mice Role