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作者选择交感神经处于高度紧张的运动状态的健康男性作为受试者,研究了静注超短效β阻滞剂艾司洛尔(Esmolol)对心率、血压和PR间期的影响。受试者在早餐以后不再进食,于下午进行试验。13例受试者,用药前通过自行车测力计方法逐步增大工作负荷,使心率达到运动状态[静止期心率十0.5×(按年龄预测最高心率-静止期心率)]并持续3分钟后,静脉推注本品单剂10～300mg,30秒推完,每个受试者先后用不同剂量本品试验2次,间隔1小时。另8例受试者按同法达到运动状
The authors selected healthy men whose sympathetic nerves were in a state of high stress as subjects and studied the effects of intraventricular injection of esmolol on heart rate, blood pressure and PR interval. Subjects no longer eat after breakfast and run in the afternoon. Thirteen subjects, before working with the bicycle dynamometer gradually increase the workload, the heart rate to exercise [quiescent heart rate of 10 × 10 (age-based maximum heart rate - resting heart rate)] and continued for 3 minutes, Intravenous injection of this product single dose of 10 ~ 300mg, 30 seconds push finished, each subject has used different doses of this product test 2 times, an interval of 1 hour. The other 8 subjects according to the same law to achieve the sport