论文部分内容阅读
目的:研究高血压患者颈-股动脉脉搏波传导速度(CFPWV)、颈-桡动脉脉搏波传导速度(CRP-WV)、颈-踝动脉脉搏波传导速度(CAPWV)和反射波增强指数(AI)的变化及相关因素。方法:选取高血压患者237例(高血压组)和与其性别、年龄相匹配的健康者253名(对照组),采用自动脉搏波传导速度(PWV)分析仪测定不同部位PWV,采用桡动脉压力波分析仪测定AI,并检测空腹血糖、血脂、尿酸等血液生化指标。结果:与对照组比较,高血压组的CFPWV、CRPWV、CAPWV均显著增加(均P<0.01),而AI无明显变化(P=0.194)。多元逐步回归分析显示,年龄[β(标准化系数)=0.324,P<0.01]、收缩压(β=0.284,P<0.01)和性别(β=-0.126,P<0.05)是CFPWV的独立相关因素(R2=0.230);性别(β=-0.353,P<0.01)和舒张压(β=0.175,P<0.01)是CRPWV的独立相关因素(R2=0.167);收缩压(β=0.222,P<0.01)、年龄(β=0.174,P<0.01)和性别(β=-0.108,P<0.05)是CAPWV的独立相关因素(R2=0.105);身高(β=-0.399,P<0.01)、心率(β=-0.352,P<0.01)和收缩压(β=0.140,P<0.01)是AI的独立相关因素(R2=0.290)。结论:高血压患者各部位PWV显著增加,CFPWV和CAPWV主要相关因素相同(年龄、收缩压和性别),但强度略有不同;CRPWV的主要影响因素是性别和舒张压。AI无明显变化,可能不是反映动脉僵硬的敏感、可靠指标。
AIM: To investigate the relationship between carotid-femoral artery pulse wave velocity (CFPWV), carotid-radial artery pulse wave velocity (CRP-WV), carotid-ankle pulse wave velocity (CAPWV) and reflex enhancement index ) Changes and related factors. Methods: A total of 237 hypertensive patients (hypertension group) and 253 healthy controls (gender, age) were enrolled in this study. The PWV was measured by PWV analyzer. Radial artery pressure Wave Analyzer was used to measure AI and to detect blood biochemical parameters such as fasting blood glucose, blood lipid and uric acid. Results: Compared with the control group, the levels of CFPWV, CRPWV and CAPWV in hypertension group were significantly increased (all P <0.01), while AI did not change significantly (P = 0.194). Multiple stepwise regression analysis showed that age (β = 0.324, P <0.01), systolic blood pressure (β = 0.284, P <0.01) and sex (β = -0.126, P <0.05) were independent correlates of CFPWV (R2 = 0.230). The correlation between CRPWV (R2 = 0.167) and systolic blood pressure (β = 0.222, P < 0.01), age (β = 0.174, P <0.01) and gender (β = -0.108, P <0.05) were independent correlates of CAPWV (R2 = 0.105) (β = -0.352, P <0.01) and systolic blood pressure (β = 0.140, P <0.01) were independently associated with AI (R2 = 0.290). CONCLUSIONS: PWV was significantly increased in all parts of hypertensive patients, and the main relevant factors of CFPWV and CAPWV were the same (age, systolic blood pressure and sex), but the intensity was slightly different. The main influencing factors of CRPWV were gender and diastolic blood pressure. AI did not change significantly and may not be a sensitive, reliable indicator of arterial stiffness.