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目的：研究安乃近溶液鼻粘膜吸收规律。方法：以大鼠在体鼻循环法为实验模型，考察循环液的体积、流速等对安乃近鼻粘膜吸收的影响。并在体积、流速确定的条件下，考查循环液浓度不同时，安乃近鼻粘膜吸收规律。结果：循环液体积越大，单位时间内粘膜吸收百分率越小；当流速较小时，随着流速的增加，吸收速度常数Ｋ增大，流速超过２．０ｍｌ·ｍｉｎ－１后，Ｋ显著减小；以循环液体积为３ｍｌ，流速２．０ｍｌ·ｍｉｎ－１，考察了５０，１００，１５０，２００ｇ·Ｌ－１安乃近溶液鼻粘膜吸收规律，表明不同浓度的安乃近鼻粘膜吸收速度为一常数。结论：安乃近溶液鼻粘膜吸收机制为被动扩散，吸收符合一级动力学，吸收速度常数Ｋ为０．０２２１９ｍｉｎ－１。
Objective: To study the nasal mucosa absorption of metamizole solution. Methods: The rat nasal circulation method was used as an experimental model to investigate the effect of circulating fluid volume and flow rate on absorption of nasal mucosa. Under the conditions of volume and flow rate, nasal absorption of nasal mucosa was detected when the concentration of circulating fluid was different. Results: The larger the volume of circulating fluid, the smaller the mucosal absorption percentage per unit time. When the flow rate was small, the absorption rate constant K increased with the flow rate increasing. When the flow rate exceeded 2.0ml · min-1, K decreased significantly ; The volume of circulating fluid was 3ml, the flow rate of 2.0ml · min-1, 50,100,150,200 g · L-1 solution of nasal mucosa absorption was investigated, indicating that different concentrations of nasal absorption rate of nasal mucosa As a constant. CONCLUSION: The absorption mechanism of nasal mucosa in metamizole solution is passive diffusion, and the absorption follows first-order kinetics. The absorption rate constant K is 0.02219min-1.