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成年神经再生在各种脑损伤、神经系统变性疾病的修复中发挥了重要的作用。在啮齿类和灵长类动物脑中,其主要发生在侧脑室(lateral ventricle,LV)的脑室下区(subventricular zone,SVZ)和海马齿状回(dentate gyrus,DG)颗粒下区(subgranular zone,SGZ)。神经干细胞(neural stem cells,NSCs)的增殖与分化之间的平衡调控是成年神经再生的重要机制。成年神经再生过程包含几个阶段,每个阶段均受到多种内源性和外源性因素的调节。Notch信号通路在成年NSCs的维持中发挥了重要的作用。该文将对Notch信号通路在脑生发区NSCs的维持与神经再生中的作用机制及其研究进展进行综述。
Adult nerve regeneration plays an important role in the repair of various brain injuries and degenerative diseases of the nervous system. In rodents and primates, it mainly occurs in the subventricular zone (SVZ) of the lateral ventricle (LV) and in the subgranular zone of the dentate gyrus (DG) , SGZ). The balance between proliferation and differentiation of neural stem cells (NSCs) is an important mechanism of adult nerve regeneration. Adult nerve regeneration involves several phases, each of which is regulated by a variety of endogenous and exogenous factors. Notch signaling pathway plays an important role in the maintenance of adult NSCs. This article reviews the mechanism of Notch signaling pathway in the maintenance and regeneration of NSCs in brain germinal region and its research progress.