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慢性活动性丙型肝炎伴肝硬化病人常发生肝细胞癌。干扰素似乎对某些患者有作用,但其是否防止癌变尚不清,为此进行了下列研究。 1987年1月至1991年7月间转来大阪市大学医院共136例HCV感染伴肝硬变的患者。试验对象符合下列条件:(1)ALT异常1年以上;(2)HBsAg阴性,并排除酒精性及自身免疫性肝病等其他原因。所有对象Child-Pugh分级均属A级,且无严重血小板减少(>50000/μl),抗HIV阴性,HCV RNA阳性,超声、CT等检查排除肝细胞癌。最终入选者90例,随机归于IFN-α组或对照组,各45例,其中IFN-a组38例及对照组32例作了肝组织
Chronic active hepatitis C patients with liver cirrhosis often occur in hepatocellular carcinoma. Interferon seems to have a role in some patients, but whether it is unclear whether it will prevent cancer, the following study was conducted. Between January 1987 and July 1991, a total of 136 HCV-infected patients with cirrhosis were transferred to Osaka University Hospital. The subjects met the following criteria: (1) ALT abnormalities for more than 1 year; (2) HBsAg-negative, and excluding alcohol and other causes of autoimmune liver disease. Child-Pugh grading of all subjects was grade A, and no severe thrombocytopenia (> 50000 / μl), anti-HIV negative, positive HCV RNA, ultrasound, CT and other tests to exclude hepatocellular carcinoma. The final enrolled 90 patients were randomly assigned to IFN-α group or control group, 45 cases each, of which 38 cases of IFN-a group and 32 cases of control group made liver tissue