目的　运用动脉结扎法诱导大鼠产生颅内动脉瘤 ,建立一种真实可信的疾病模型。方法　选用S D大鼠 (体重 2 0 0～ 30 0g) 4 0只 ,实验组 30只大鼠同时结扎左侧颈总动脉和双侧肾动脉后支 ;对照组 10只大鼠未给予手术处理。实验组手术一周后 ,两组动物均以 1%盐水替代饮水喂养 3个月。取双侧大脑前动脉 眼动脉 (ACA OA)分叉处组织在光镜下进行病理学检查。结果　实验组 2 3只大鼠共发现 5个早期动脉瘤改变 ,其中 4个在动脉结扎对侧 (右侧 ) ,1个在动脉结扎同侧 (左侧 ) ;对照组双侧均未见动脉瘤样改变。结论　该方法诱导的动脉瘤位于颅内 ,且发病部位、形态与病理改变均与临床颅内动脉瘤十分相似。因此 ,该方法建立的颅内动脉瘤模型是研究该病发病机理、影响因素及探索药物或基因治疗的理想选择。 Objective To induce intracranial aneurysms in rats by arterial ligation and establish a true and reliable disease model. Methods 40 SD rats (weighing 200 ~ 300g) were selected. 30 rats in the experimental group were ligated with the common carotid artery of the left common carotid artery and bilateral posterior branches of bilateral renal arteries. 10 rats in the control group were not given surgical treatment. One week after the operation of the experimental group, both groups of animals were fed with 1% saline instead of drinking water for 3 months. The bifurcation tissues of bilateral anterior cerebral artery (ACA OA) were examined under light microscope. Results Five early aneurysms were found in the experimental group. Four of them were ligated to the contralateral artery on the right (right) and the other artery on the ipsilateral (left) artery. No artery was found on both sides of the control group Tumor-like changes. Conclusions The aneurysm induced by this method is located in the intracranial area, and its location, morphology and pathological changes are very similar to those of clinical intracranial aneurysms. Therefore, the method of establishing an intracranial aneurysm model is to study the pathogenesis of the disease, influencing factors and to explore the ideal choice of drug or gene therapy.