目的 探究银杏达莫注射液联合坎地沙坦酯治疗早期糖尿病肾病的临床疗效.方法 选取2015年5月—2016年12月在厦门市第五医院进行治疗的236例早期糖尿病肾病,随机分为对照组和治疗组,每组各118例.对照组口服坎地沙坦酯片,1片/次,1次/d.治疗组在对照组治疗基础上静脉滴注银杏达莫注射液,20 mL银杏达莫注射液加入到250 mL生理盐水,1次/d.两组均连续治疗8周.观察两组的临床疗效,同时观察两组治疗前后血肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白(TP/24 h)、总胆固醇(TC)、血流动力学指标的变化情况.结果 治疗后,对照组和治疗组的总有效率分别为83.05%、91.53%,两组比较差异有统计学意义(P<0.05).治疗后,两组患者TP/24 h、Scr、BUN、TC、血液黏度、纤维蛋白原均显著降低,同组治疗前后差异有统计学意义(P<0.05);治疗后,治疗组TP/24 h、Scr、BUN、TC、血液黏度、红细胞压积、纤维蛋白原低于对照组,两组比较差异具有统计学意义(P<0.05).结论 银杏达莫注射液联合坎地沙坦酯治疗糖尿病肾病具有较好的临床疗效,可降低患者尿微量蛋白水平,降低血液黏度,改善肾功能,具有一定的临床推广应用价值.“,”Objective To investigate the therapeutic effect of Ginkgo Leaf Extract and Dipyridamole Injection combined with candesartan cilexetil in treatment of early diabetic nephropathy. Methods Patients (236 cases) with early diabetic nephropathy in Xiamen Fifth Hospital from May 2015 to December 2016 were randomly divided into control (118 cases) and treatment (118 cases) groups. Patients in the control group were po administered with Candesartan Cilexetil Tablets, 1 tablet/time, once daily. Patients in the treatment group were iv administered with Ginkgo Leaf Extract and Dipyridamole Injection on the basis of the control group, 20 mL Ginkgo Leaf Extract and Dipyridamole Injection added into 250 mL physiological saline, once daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the changes of Scr, BUN, TP/24 h, TC, and hemodynamic indicators in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.05% and 91.53%, respectively, and there was difference between two groups (P<0.05). After treatment, TP/24 h, Scr, BUN, TC, blood viscosity, fibrinogen in two groups were decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, Scr, BUN, TP/24 h, TC, blood viscosity, erythrocyte compression, and fibrinogen in the treatment group were lower than those in the control group, and there was difference between two groups (P<0.05).Conclusion Ginkgo Leaf Extract and Dipyridamole Injection combined with candesartan cilexetil has clinical curative effect in treatment of early diabetic nephropathy, and can reduce the urinary microprotein and blood viscosity, also can improve kidney function, which has a certain clinical application value.