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本实验为进一步论证白斑发展至癌变过程中上皮组织、血管及温度之间关系,采用0.5％DMBA(9.10—dlmethy1—1.2—benzanthyacene)丙酮液诱发地鼠颊囊白斑癌变。在实验过程中用超微型压力温度同步测温仪对病损变化进行监测,用墨汁灌注法将地鼠颊囊制成透明血管片及HE组织片行血管及组织学观察。 实验表明:单纯性白斑血管扩张。癌前白斑固有层血管呈栅栏状增生、血管向癌性血管形态转变。早期癌血管增生,迂曲、扩张呈蜡肠状或囊团状,其分布呈多形性。实验过程中病损温度变化规律为单纯性白斑<癌前白斑<癌。实验结果提示,监测病损区温度,可提供临床上观察白斑的发展变化和早期诊断的手段。
In order to further demonstrate the relationship between epithelial tissues, blood vessels and temperature during the development of leukoplakia to canceration, 0.5% DMBA (9.10-dlmethy1-1.2-benzanthyacene) acetone solution was used to induce leukoplakia leukoplakia carcinogenesis. During the experiment, the change of lesions was monitored with ultra-micro pressure and temperature synchronous thermometer. The blood vessel and histological observation of the transparent vascular slice and HE tissue slice were made by ink perfusion method. Experiments show that simple white spot vasodilation. The prelaminar intrinsic layer of blood vessels showed a palisade-like hyperplasia, and the vascular shape changed to a cancerous vessel. Early cancer vascular hyperplasia, warping, expansion was waxy bowel or cystic, its distribution was polymorphic. The change of lesion temperature during the experiment was a simple leukoplakia, precancer leukemia and carcinoma. The experimental results suggest that monitoring the temperature of the affected area can provide a means for clinical observation of the development and change of white spot and early diagnosis.