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目的观察丁苯酞氯化钠注射液治疗动脉瘤性蛛网膜下腔出血(subarachnoid hemorrhage,SAH)并发迟发性脑缺血(delayed cerebral ischemia,DCI)的临床效果。方法选择2008年1月—2014年1月收治的DCI患者61例,随机分为对照组31例和观察组30例。对照组应用尼莫地平注射液10 mg/次,2次/d,持续静脉泵入,补液扩充血容量、单唾液酸四己糖神经节苷脂钠注射液40 mg+0.9%氯化钠注射液100 ml静脉滴注,1次/d,营养神经等常规治疗,观察组在对照组基础上加用丁苯酞氯化钠注射液100 ml静脉滴注,2次/d,持续2周。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果对照组总有效率为48.4%,观察组为90.0%,两组比较差异有统计学意义(χ2=12.310,P<0.05)。治疗前后、3个月后,对照组格拉斯哥预后量表(Glasgow outcome scale,GOS)评分为(3.5±1.2)分,观察组为(4.5±0.5)分,两组比较差异有统计学意义(t=4.223,P<0.05)。结论应用丁苯酞氯化钠注射液治疗动脉瘤性SAH介入治疗后DCI能明显改善预后。
Objective To observe the clinical efficacy of sodium butyrate phthalate sodium chloride injection in the treatment of subarachnoid hemorrhage (SAH) with delayed cerebral ischemia (DCI). Methods Sixty-one DCI patients who were admitted from January 2008 to January 2014 were randomly divided into control group (n = 31) and observation group (n = 30). The control group was given nimodipine injection 10 mg / time, 2 times / d, continuous intravenous infusion, rehydration expansion of blood volume, monosialotetrahexosyl ganglioside sodium injection 40 mg + 0.9% sodium chloride injection Liquid 100 ml intravenous drip, 1 time / d, nutritional nerves and other conventional treatment, the observation group in the control group plus butylphthalide sodium chloride injection 100 ml intravenous infusion, 2 times / d for 2 weeks. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 48.4% in the control group and 90.0% in the observation group. There was significant difference between the two groups (χ2 = 12.310, P <0.05). Three months after treatment, Glasgow outcome scale (GOS) score was (3.5 ± 1.2) in the control group and (4.5 ± 0.5) in the observation group, with significant difference between the two groups (t = 4.223, P <0.05). Conclusion The application of butylphthalide and sodium chloride injection in the treatment of aneurysmal SAH intervention after DCI can significantly improve the prognosis.