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对胃癌单抗ＭＧ７所识别的胃癌新的相关抗原ＭＧ７Ａｓ、ＴＡＧ７２、ＣＡ１９．９（均为ＩＲＭＡ法）进行了前瞻性规范的诊断试验对照研究，评价ＭＧ７Ａｇ及其联合应用诊断胃癌的价值。结果：ＲＯＣ曲线法选择ＭＧ７Ａｇ界值为７．５ｋＵ／Ｌ。ＭＧ７Ａｇ、ＴＡＧ７２、ＣＡ１９－９诊断胃癌的敏感性分别为４８．８％、４５．３％、３８．５％，无显著性差别（Ｐ＞０．０５）；３者特异性分别为９２．８％、９１．６％、９２．８％（Ｐ＞０．０５）。ＭＧ７Ａｇ与ＴＡＧ７２，ＣＡ１９－９诊断Ⅲ、Ⅳ期胃癌的敏感性显著高于Ⅰ、Ⅱ期，其中ＭＧ７Ａｇ分别为６９．６％和２７．３％。ＭＧ７Ａｇ是一种有价值的胃癌标志物，与ＴＡＧ７２或（和）ＣＡ１９－９联合应用可显著提高诊断胃癌的敏感性。
The gastric cancer monoclonal antibody MG7 recognized the new gastric cancer associated antigens MG7As, TAG72, CA19.9 (all IRMA method) a prospective and standardized diagnostic test controlled study to evaluate the value of MG7Ag and its combination in the diagnosis of gastric cancer. Results: The ROC curve method selected the MG7Ag cutoff value as 7.5 kU/L. The sensitivity of MG7Ag, TAG72, and CA19-9 in the diagnosis of gastric cancer were 48.8%, 45.3%, and 38.5%, respectively, and there was no significant difference (P>0.05). The specificity of the three individuals was 92.8 respectively. %, 91.6%, 92.8% (P>0.05). The sensitivity of MG7Ag and TAG72, CA19-9 in the diagnosis of stage III and IV gastric cancer was significantly higher than that of stage I and II, and MG7Ag was 69.6% and 27.3%, respectively. MG7Ag is a valuable gastric cancer marker, and its combination with TAG72 or (and) CA19-9 can significantly improve the sensitivity of the diagnosis of gastric cancer.