众所周知,环孢素有明显的肾毒性,然而,环孢素相关性高血压(CAH)的发生率明显高于其肾毒性。究其机理不明,有人认为CAH可能继发于伴有中心容量扩大的钠潴留。他们综合评价了口服环孢素对饮食钠的慢性调节和急性扩容的分泌反应的作用。方法:分慢性8天饮食研究和急性盐水扩容研究两部分,均在16～21公斤的蒙古狗中进行,所有狗配对喂养,每天予恒定食物,允许自由饮水。实验组 It is well-known that cyclosporine has significant nephrotoxicity, however, the incidence of cyclosporine-related hypertension (CAH) is significantly higher than its nephrotoxicity. The mechanism is unknown, some people think that CAH may be secondary to the expansion of the center with sodium retention. They evaluated the effects of oral cyclosporine on the chronic regulation of dietary sodium and the secretory response to acute dilatation. METHODS: Chronic 8-day diet studies and acute saline dilatation studies were conducted in Mongolian dogs of 16-21 kg with all dogs being paired daily for constant food, allowing free access to water. test group