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面向全自动生化分析仪的电解质测试需求,结合流动注射分析法(FIA)与离子选择电极法(ISE),在理论上对动态的电解质分析方法进行分析讨论,为电解质模块的研发提供了理论基础。利用嵌入式技术实现模块的研制,并进行电解质测量实验,对模块的准确度、精密度、线性、稳定性、交叉污染率等5个方面进行评价,实验结果显示,K+、Na+、Cl-相对偏差和交叉污染率均在1%之下,变异性系数分别为0.40%、0.22%、0.66%,线性误差分别为-1.10%、-0.68%、-0.46%,稳定性分别为1.11%、0.76%、1.39%。临床实验结果表明,该电解质模块可以满足临床应用的要求。与传统电解质分析仪相比,该电解质模块可与全自动生化分析仪联用,测试速度高达150样品/h,在高速电解质分析领域具有一定的应用前景。
In order to meet the needs of electrolyte testing of automatic biochemical analyzers, the dynamic electrolyte analysis method is theoretically analyzed and discussed with the combination of flow injection analysis (FIA) and ion selective electrode (ISE), which provides a theoretical basis for the development of electrolyte modules . The module was developed by embedded technology, and the electrolyte measurement experiment was carried out to evaluate the accuracy, precision, linearity, stability and cross-contamination rate of the module. The experimental results showed that K +, Na +, Cl- The deviations and cross-contamination rates were all below 1% with variability coefficients of 0.40%, 0.22% and 0.66%, linear errors of -1.10%, -0.68% and -0.46%, respectively, with stability of 1.11% and 0.76 %, 1.39%. Clinical experimental results show that the electrolyte module can meet the requirements of clinical applications. Compared with the traditional electrolyte analyzer, the electrolyte module can be used with automatic biochemical analyzer, the test speed of up to 150 samples / h, in the field of high-speed electrolyte analysis has a certain application prospects.