AIM: To search some compounds that have anti-depressive activity from Helicid WN7-6 and its derivatives, and to explore their structure-function relationship. METHODS: 21 compounds including WN7-6, the lead compound were screened for antidepressant effect by the behavioral despair models(tail suspension test and the forced swimming test). And to study their stimulative effect on central nerve system(CNS) by mice autonomic activity test. RESULTS: Results shown that 11 of these compounds could decrease immobile time in suspend tail test and 6 compounds had the similar effect in force swimming test, compared with that of control group, the immobile time was obviously reduced (P<0.05, P<0.01). The results of autonomic activity test indicated that only 7 compounds could inhibit the activities of CNS (P<0.05, P<0.01). CONCLUSION: 30%-50% of these derivatives have anti-depressive activities, and much attention should be paid to further researches. AIM: To search some compounds that have anti-depressive activity from Helicid WN7-6 and its derivatives, and to explore their structure-function relationship. METHODS: 21 compounds including WN7-6, the lead compound were screened for antidepressant effect by the behavioral Despair models(tail suspension test and the forced swimming test). And to study their stimulative effect on central nerve system(CNS) by mice autonomic activity test. RESULTS: Results shown that 11 of these compounds could decrease immobile time in suspend tail test and 6 compounds had the similar effect in force swimming test, compared with that of control group, the immobile time was reduced (P<0.05, P<0.01). The results of autonomic activity test indicated that only 7 compounds could inhibit the activities of CNS (P<0.05, P<0.01). CONCLUSION: 30%-50% of these derivatives have anti-depressive activities, and much attention should be paid to further researches.