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目的:探讨急性心肌梗死(AMI)患者血清脂联素水平变化及与C-反应蛋白(CRP)的关系。方法:AMI患者25例(AMI组),冠状动脉造影基本正常的30例为对照组,分别检测其血清脂联素、高敏CRP(hs-CRP)水平,并比较两者的相互关系。结果:AMI组血清脂联素水平的对数值明显低于对照组[(3.07±0.42)∶(3.67±0.33)μg/L,P<0.01],hs-CRP的对数值则高于对照组[(1.38±0.52)∶(0.72±0.36)mg/L,P<0.01],两者呈明显负相关(r=-0.37,P<0.01)。结论:血清脂联素水平降低与AMI发生有关,脂联素可能参与了冠状动脉粥样硬化的发展过程。
Objective: To investigate the changes of serum adiponectin level and the relationship with C-reactive protein (CRP) in patients with acute myocardial infarction (AMI). Methods: Twenty-five patients with AMI (AMI group) and 30 patients with normal coronary angiography were selected as the control group. Serum levels of adiponectin and high-sensitivity CRP (hs-CRP) were measured and their correlations were compared. Results: The logarithm of serum adiponectin level in AMI group was significantly lower than that in control group [(3.07 ± 0.42) vs (3.67 ± 0.33) μg / L, P <0.01], while the logarithm of hs-CRP was higher in AMI group than in control group [ (1.38 ± 0.52) vs (0.72 ± 0.36) mg / L respectively, P <0.01]. There was a significant negative correlation between them (r = -0.37, P <0.01). Conclusion: The decrease of serum adiponectin level is related to the occurrence of AMI. Adiponectin may be involved in the development of coronary atherosclerosis.