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目的：探讨醒脑静注射液对急性大灶性脑梗塞患者炎症反应的影响。方法：４２ 例患者随机分为２组：对照组２１ 例（ 常规方法治疗） ，醒脑静组２１ 例（ 常规加醒脑静注射液治疗） ，观察治疗前后血清肿瘤坏死因子（ＴＮＦ） 、可溶性血管细胞粘附分子－ １（ＳＶＣＡＭ－ １） 的变化与临床疗效，并与１９ 名健康人对照。结果：两组患者治疗前血清ＴＮＦ、ＳＶＣＡＭ－ １ 均显著高于健康组，治疗后显著改善，而且以醒脑静组改善更为明显；醒脑静组治愈、显效率也显著高于对照组（５７－１ ％ 与３３－３ ％ ，Ｐ＜ ０ ．０５） 。结论：醒脑静注射液对炎症反应的抑制可作为其治疗脑梗塞重要机理
Objective: To investigate the effects of Xingnaojing injection on inflammatory reaction in patients with acute focal cerebral infarction. Methods: Forty-two patients were randomly divided into two groups: control group (21 cases) and Xingnaojing group (21 cases). The levels of serum tumor necrosis factor (TNF), soluble Vascular cell adhesion molecule - 1 (SVCAM - 1) changes and clinical efficacy, and 19 healthy controls. Results: The levels of serum TNF and SVCAM-1 in two groups before treatment were significantly higher than those in healthy group, and were significantly improved after treatment. The improvement was more obvious in Xingnaojing group, and the recovery rate in Xingnaojing group was significantly higher than that in control group (57-1% vs. 33-3%, P <0.05). Conclusion: Xingnaojing injection can inhibit the inflammatory reaction as an important mechanism of cerebral infarction