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目的:观察力尔凡联合顺铂进行胸腔内注射治疗恶性胸腔积液的疗效和不良反应。方法:32例恶性胸腔积液病人,经B超定位行常规胸腔穿刺抽液术,尽量抽尽胸水后将力尔凡(30~40)mg+生理盐水30ml+顺铂60mg+地塞米松10mg缓慢注入患侧胸腔内,每周1次,一般2~4次。结果:CR10例,PR16例,NC6例,RR81.3%。所有病人在治疗过程中均未见明显发热及胃肠道反应,无明显肝肾功能损伤及心电图改变,有3例出现白细胞及血小板轻度减少。结论:力尔凡联合顺铂进行胸腔内注射治疗恶性胸腔积液是一种安全有效低毒的治疗方法,值得临床推广使用。
Objective: To observe the efficacy and adverse reactions of Lerfan and cisplatin in the treatment of malignant pleural effusion with intrapleural injection. Methods: Thirty-two patients with malignant pleural effusion were treated with routine thoracentesis by B-ultrasound. After pleural effusion was exhausted, Lerfan (30~40) mg + normal saline 30ml + cisplatin 60mg + dexamethasone 10mg was slowly injected into patients. Side of the chest cavity, once a week, usually 2 to 4 times. Results: There were 10 cases of CR, 16 cases of PR, 6 cases of NC, and 81.3% of RR. All patients did not have obvious fever and gastrointestinal reactions, no significant liver and kidney damage, and electrocardiogram changes during the treatment. There were 3 cases of mild reduction of white blood cells and platelets. Conclusion: Intrapleural injection of Lerfan and cisplatin for the treatment of malignant pleural effusion is a safe, effective and low-toxic treatment. It is worthy of clinical application.